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Srikanth, J.
- Antidepressant-Like Effects of the Ethanolic Extract of Albizzia lebbeck (Linn) Leaves in Animal Models of Depression
Authors
1 Department of Pharmacognosy, Vels School of Pharmaceutical Sciences, Vels University, Pallavaram, Chennai–117, Tamil Nadu, IN
2 Department of Pharmacognosy, Vels School of Pharmaceutical Sciences, Vels University, Pallavaram, Chennai-117, Tamil Nadu, IN
3 Department of Pharmacology, Sri Ramachandra College of Pharmacy, Sri Ramachandra University, Porur, Chennai-600116, Tamilnadu, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 2, No 1 (2010), Pagination: 30-33Abstract
The present study was designed to investigate the antidepressant effects of Albizzia lebbeck leaves in various animal depression models. The alcoholic extract (70% v/v ethanol) of Albizzia lebbeck leaves (200 and 400 mg/kg. p.o) was administered once daily for seven successive days to separate groups of young male swiss albino mice. The immobility periods of control and treated mice were recorded in two behavioral despair models forced swim test (FST), tail suspension test (TST) and the effect of extract on locomotor function of mice was studied using actophotometer. The antidepressant-like effect of tested drug was compared to that of imipramine (15 mg/kg. p.o) and fluoxetine (20mg/kg.p.o). The leaf extract at doses of 200 and 400 mg/kg significantly decreased the duration of immobility time in a dose dependent manner in both FST and TST.
The extract did not show significant effect on locomotor activity of mice. The efficacy of tested extract was found to be comparable to that of imipramine and fluoxetine. Our results suggested that the ethanolic extract of Albizzia lebbeck leaves exerts antidepressant-like effect.
Keywords
Albizzia lebbeck, Depression, Forced Swim Test, Tail Suspension Test.
- Pharmacognostical and Preliminary Phytochemical Studies on the Stem Bark of Soymida febrifuga (Roxb)
Authors
1 Department of Pharmacognosy, VELS College of Pharmacy, VELS University, Pallavaram, Chennai-600 043, Tamil Nadu, IN
2 Department of Pharmacology, Sri Ramachandra College of Pharmacy, Sri Ramachandra University, Porur, Chennai-600 116, Tamil Nadu, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 1, No 3 (2009), Pagination: 213-216Abstract
Soymida febrifuga is commonly known as Shem in Tamil and Indian red wood in English. In Ayurveda the bark is used as a good cure for ulcer, leprosy and dysentery. In unani the bark is used as an astringent to the bowel and useful in fever. The bark is also used in vaginal infection, rheumatic swellings, oedema, wounds, dental problems, uterine bleeding and malarial fever. There was no report on the pharmacognostic study of the plant and hence the present investigation deals with the anatomical, microscopical, powder microscopy, physio-chemical, fluorescence analysis, Thin layer chromatography and high performance thin layer chromatography. The study revealed the presence of drugs of calcium oxalate, tannins dilated phloem rays, sieve elements and schlerids. Phytochemical studies showed the presence of steroids, terpenoids, flavanoids and tannins.
Keywords
Soymida febrifuga, TLS, RLS.- Anthelminthic Activity of Sapindus emarginatus Vahl
Authors
1 Sri Ramachandra College of Pharmacy, Sri Ramachandra University, Porur, Chennai-600116, Tamilnadu, IN
2 Dept. of Pharmacology and Toxicology, C.L.Baid Metha College of Pharmacy, Jyothi Nager, Thoraippakkam, Chennai-600 097, Tamilnadu, IN